Doxy-PEP | Post-Exposure Medication to Prevent STIs

𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 is the use of the antibiotic “𝘋𝘰𝘹𝘺𝘤𝘺𝘤𝘭𝘪𝘯𝘦” to prevent sexually transmitted infections (STIs) after having sex without using a condom, whether it be penetrative sex or oral sex. Currently, 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 is being used in many countries around the world, including Thailand.

What STIs can 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 prevent?

Studies in France, the United States, and Kenya have shown that 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 can significantly reduce the incidence of chlamydia and syphilis infections compared to a placebo group. It has an effectiveness rate of approximately 70–90% in preventing chlamydia and syphilis, and about 30–60% in reducing gonorrhea infections.

Who can use 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣?

Men who have sex with men (MSM) and transgender women. Studies in these populations from other countries have shown that 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 is highly effective in reducing chlamydia and syphilis infections, and also effective in reducing gonorrhea infections (in countries where tetracycline-resistant gonorrhea is still at low levels). However, there is no current evidence supporting its use in women who have sex with men, and thus it is not recommended for that group. It is advised only for individuals at high risk of STI exposure through sexual activity.

How to use 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣

It is recommended to take the medication within 72 hours after having unprotected sex. Take 100 mg of doxycycline, 2 tablets at a time, not exceeding 3 times or 6 tablets per week.

Are there any dangerous side effects of 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣?

Possible side effects of 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 include esophageal irritation, stomach pain, nausea, vomiting, increased skin sensitivity to sunlight, and redness or burning after sun exposure. Therefore, it is recommended to consult a healthcare professional before using 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 to ensure proper and safe usage.

The difference between 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 and PEP

• 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 involves taking oral doxycycline to prevent chlamydia and syphilis infections after unprotected sex.
• PEP (Post-Exposure Prophylaxis) is the use of antiretroviral drugs in oral form to prevent HIV infection after exposure through sex or contact with blood or bodily fluids from an HIV-positive individual.

Therefore, 𝗗𝗼𝘅𝘆-𝗣𝗘𝗣 cannot prevent HIV infection after exposure. Likewise, PEP cannot prevent chlamydia, gonorrhea, or syphilis infections resulting from unprotected sex.